The major trend in clinical trials is the proliferation of decentralized and hybrid research models. These make it possible to accelerate the pace of studies involving patients to determine the effects of medicinal products or medical techniques and address their safety at the time. The growing use of artificial intelligence (AI), big data analytics, telemedicine, blockchain technology, and wearable electronics saves time and reduces research costs significantly. Optimizing relevant data acquisition is accompanied by boosting patient well-being and experience.